Sep 7, 2020
Postdoctoral researcher and medical bioinformatician, Irina
Chelysheva, is a member of the Oxford Vaccine Group. Today, she
discusses her work and knowledge regarding vaccine research and
development.
Press play to discover:
Chelysheva begins by shedding light on what it means to be a
bioinformatician and the important role of bioinformatics in
science and research. She also explains how next-generation
sequencing can be applied to the area of vaccine research and
development. For example, a person’s human leukocyte antigen (HLA)
system could play a role in how effectively a vaccine works for
them.
Sequencing allows you to see the mutations, HLA, and gene
expression by performing RNA/ transcriptome sequencing. It
also allows you to distinguish between groups of people who have
specific genes or pathways activated and groups of people who do
not, which can have implications for how a person will react to a
vaccine.
Chelysheva also talks about the normal immune response to
vaccination and overreactions by the immune system in response
to
vaccination, and shares the details and findings of her
work on vaccines and genetic sequencing. One of the main questions
she aims to answer is why T cells might be produced by one organism
but not another organism after vaccination. In addition, she
discusses why some vaccines fail to work, why they are challenging
to develop, her take on a COVID-19 vaccine, Oxford Nanopore
Technologies, and more.
Check out https://www.ovg.ox.ac.uk/team/irina-chelysheva
for more.
Available on Apple
Podcasts: apple.co/2Os0myK